Our lab broadly focuses on developing molecular reporters to noninvasively look at biological processes in living systems. Within this goal, we take a special interest in imaging anaerobic microorganisms and vertebrate animals. These two physiologically relevant contexts share the unique misfortune of being incompatible with the green fluorescent protein (GFP), undoubtedly the best-established reporter gene for imaging cellular function. My lab develops new classes of imaging tools that can penetrate deep tissues (by magnetic resonance) or become fluorescent without oxygen (by binding to chromophores), thereby expanding the benefits of reporter gene imaging to probe "invisible" biological processes. Our pursuit is fueled by the growing need for technologies that allow us to spy into biological systems with the precision needed to unearth mechanisms underlying everything from infection to metastasis to neural processing.